Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up examines the principles and strategies involved in developing efficient synthetic routes for the large-scale manufacture of pharmaceutical compounds. The book focuses on the challenges of transforming laboratory-scale chemical syntheses into robust, economical, safe, and commercially viable industrial processes. It discusses route selection, process optimization, impurity control, reaction scale-up, process safety, and cost-effective manufacturing strategies for active pharmaceutical ingredients (APIs). Through detailed case studies of major pharmaceutical products, including pioglitazone, escitalopram, venlafaxine, quetiapine, montelukast, lansoprazole, salmeterol, and atorvastatin, the text demonstrates how process chemists redesign and improve synthetic pathways to enhance yield, efficiency, product quality, and environmental performance. Combining practical industrial experience with modern process chemistry concepts, the book serves as a valuable reference for pharmaceutical scientists, process chemists, chemical engineers, and professionals involved in drug development and pharmaceutical manufacturing.

Ngôn ngữ:	eng
Tác giả:	Harrington, Peter J.
Thông tin nhan đề:	Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up
Nhà xuất bản:	John Wiley & Sons, Inc.
Loại hình:	Giáo trình sách, tham khảo / Bộ sưu tập: Công nghệ Hóa
Mô tả vật lý:	369p.
Năm xuất bản:	2011