Fundamentals of Medicinal Chemistry provides a comprehensive introduction to the principles and applications of medicinal chemistry in modern drug discovery and development. The book explains how the chemical structure of biologically active compounds influences their pharmacological properties and therapeutic effects, linking concepts from organic chemistry, biochemistry, pharmacology, and pharmaceutical sciences. The text covers biological molecules, drug targets, mechanisms of drug action, and the processes involved in discovering and developing new medicines. It examines key approaches to drug design, including structure–activity relationships (SAR), quantitative structure–activity relationships (QSAR), computer-aided drug design, and combinatorial chemistry. The book also discusses pharmacokinetics, drug metabolism, lead compound identification and optimization, analogue synthesis, and strategies for improving drug efficacy and safety. Through numerous examples from clinically important therapeutic areas, the author illustrates how medicinal chemists design and optimize drug molecules to interact selectively with biological targets. Combining fundamental theory with practical applications, the book serves as an essential resource for students of medicinal chemistry, pharmacy, pharmaceutical sciences, biochemistry, and related biomedical disciplines.

Ngôn ngữ:	eng
Tác giả:	Thomas, Gareth
Thông tin nhan đề:	Fundamentals of Medicinal Chemistry
Nhà xuất bản:	John Wiley & Sons, Ltd.
Loại hình:	Giáo trình sách, tham khảo / Bộ sưu tập: Công nghệ Hóa
Mô tả vật lý:	285p.
Năm xuất bản:	2003